Not necessarily a bold prediction, to be honest.
We are playing at home, are on a hot streak, and the defense should shut down Alex Smith this time around.
For the niners, they have already clinched the division and are probably going to be without Patrick Willis. There may be a sense of apathy in this game for them, despite playing against a division rival. Remember when we clinched early in 2008? The team fell asleep until Week 17.
I think the Cardinals will be playing with more emotion. Just read Dockett's tweets for the week. He'll be out for blood.