Predicting winners in MLB on Thursday, March 26th, 2026

[ASFN Admin]

Winning in MLB on a daily basis is one of the toughest challenges in sports. With 162 games, constant lineup changes, pitching matchups, and the unpredictable nature of baseball, picking winners isn’t about guessing—it’s about analyzing matchups and picking up on patterns. Every day presents a new slate, new opportunities, and new value. From analyzing starting pitchers and bullpen usage to identifying hot lineups and favorable matchups, success comes from staying consistent and trusting the process over the long haul. Here are today’s MLB predictions for final scores and the winners around the league.


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Pirates at Mets​

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Sep 4, 2025; Pittsburgh, Pennsylvania, USA; Pittsburgh Pirates starting pitcher Paul Skenes (30) delivers a pitch against the Los Angeles Dodgers during the first inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

• Pitching Matchup: Paul Skenes vs. Freddy Peralta
• Score Prediction: 4-3
• Winner: Mets

White Sox at Brewers​

• Pitching Matchup: Shane Smith vs. Jacob Misiorowski
• Score Prediction: 6-3
• Winner: Brewers

Nationals at Cubs​

• Pitching Matchup: Cade Cavali vs. Matthew Boyd
• Score Prediction: 7-2
• Winner: Cubs

Twins at Orioles​

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Sep 26, 2025; Philadelphia, Pennsylvania, USA; Minnesota Twins pitcher Joe Ryan (41) throws a pitch during the second inning against the Philadelphia Phillies at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

• Pitching Matchup: Joe Ryan vs. Trevor Rogers
• Score Prediction: 4-1
• Winner: Orioles

Red Sox at Reds​

• Pitching Matchup: Garrett Crochet vs. Andrew Abbott
• Score Prediction: 8-5
• Winner: Red Sox

Tigers at Padres​

• Pitching Matchup: Tarik Skubal vs. Nick Pivetta
• Score Prediction: 5-4
• Winner: Padres

Angels at Astros​

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Sep 24, 2025; West Sacramento, California, USA; Houston Astros pitcher Hunter Brown (58) delivers a pitch against the Athletics in the first inning at Sutter Health Park. Mandatory Credit: Cary Edmondson-Imagn Images

• Pitching Matchup: Jose Soriano vs. Hunter Brown
• Score Prediction: 7-5
• Winner: Astros

Rays at Cardinals​

• Pitching Matchup: Drew Rasmussen vs. Matthew Liberatore
• Score Prediction: 6-4
• Winner: Rays

Rangers at Phillies​

• Pitching Matchup: Nathan Eovaldi vs. Christopher Sanchez
• Score Prediction: 3-2
• Winner: Phillies

Diamondbacks at Dodgers​

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Los Angeles Dodgers pitcher Yoshinobu Yamamoto (18) pitches against the Toronto Blue Jays in the first inning during game two of the 2025 MLB World Series at Rogers Centre. Credit: John E. Sokolowski-Imagn Images

• Pitching Matchup: Zac Gallen vs. Yoshinobu Yamamoto
• Score Prediction: 8-3
• Winner: Dodgers

Guardians at Mariners​

• Pitching Matchup: Tanner Bibee vs. Logan Gilbert
• Score Prediction: 3-1
• Winner: Mariners

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