Predicting the winner of every MLB game on Friday, April 10th, 2026

[ASFN Admin]

Winning in MLB on a daily basis is one of the toughest challenges in sports. With 162 games, constant lineup changes, pitching matchups, and the unpredictable nature of baseball, picking winners isn’t about guessing—it’s about analyzing matchups and picking up on patterns. Every day presents a new slate, new opportunities, and new value. From analyzing starting pitchers and bullpen usage to identifying hot lineups and favorable matchups, success comes from staying consistent and trusting the process over the long haul. Here are today’s MLB predictions for final scores and the winners around the league.


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Pirates vs. Cubs​

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Aug 21, 2025; Chicago, Illinois, USA; Chicago Cubs starting pitcher ***** Imanaga (18) delivers a pitch against the Milwaukee Brewers during the first inning at Wrigley Field. Mandatory Credit: Kamil Krzaczynski-Imagn Images

• Pitching Matchup: Mlodzinski vs. Imanaga
• Score Prediction: 6-2
• Winner: Cubs

Diamondbacks vs. Phillies​

• Pitching Matchup: Soroka vs. Luzardo
• Score Prediction: 5-4
• Winner: Phillies

Marlins vs. Tigers​

• Pitching Matchup: Paddack vs. Montero
• Score Prediction: 4-2
• Winner: Marlins

Angels vs. Reds​

• Pitching Matchup: Kochanowicz vs. Burns
• Score Prediction: 6-3
• Winner: Reds

Twins vs. Blue Jays​

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Apr 5, 2026; Minneapolis, Minnesota, USA; Minnesota Twins starting pitcher Simeon Woods Richardson (24) throws to the Tampa Bay Rays in the second inning at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

• Pitching Matchup: Woods Richardson vs. Corbin
• Score Prediction: 5-2
• Winner: Twins

Yankees vs. Rays​

• Pitching Matchup: Gil vs. Matz
• Score Prediction: 4-3
• Winner: Yankees

Athletics vs. Mets​

• Pitching Matchup: Ginn vs. Holmes
• Score Prediction: 4-1
• Winner: Mets

Guardians vs. Braves​

• Pitching Matchup: Cecconi vs. Elder
• Score Prediction: 5-3
• Winner: Braves

Giants vs. Orioles​

• Pitching Matchup: Roupp vs. Baz
• Score Prediction: 3-2
• Winner: Orioles

White Sox vs. Royals​

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Mar 30, 2026; Kansas City, Missouri, USA; Kansas City Royals starting pitcher Kris Bubic (50) delivers a pitch against the Minnesota Twins during the fourth inning at Kauffman Stadium. Mandatory Credit: Denny Medley-Imagn Images

• Pitching Matchup: Martin vs. Bubic
• Score Prediction: 5-4
• Winner: Royals

Nationals vs. Brewers​

• Pitching Matchup: Irvin vs. Patrick
• Score Prediction: 7-2
• Winner: Brewers

Red Sox vs. Cardinals​

• Pitching Matchup: Early vs. May
• Score Prediction: 6-4
• Winner: Red Sox

Astros vs. Mariners​

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Apr 4, 2026; Anaheim, California, USA; Seattle Mariners starting pitcher Emerson Hancock (26) throws a pitch against the Los Angeles Angels during the first inning at Angel Stadium. Mandatory Credit: Jonathan Hui-Imagn Images

• Pitching Matchup: Imai vs. Hancock
• Score Prediction: 5-3
• Winner: Mariners

Rockies vs. Padres​

• Pitching Matchup: Sugano vs. Buehler
• Score Prediction: 8-4
• Winner: Padres

Rangers vs. Dodgers​

• Pitching Matchup: Rocker vs. Glasnow
• Score Prediction: 9-5
• Winner: Dodgers

Conclusion:​

At the end of the day, picking winners in Major League Baseball is a marathon, not a sprint. There will be bad beats, unexpected blowups, and nights where nothing goes according to plan; that’s the nature of baseball.

The key is staying disciplined, trusting the process, and finding edges over time. Stick with the matchups, follow the trends, and don’t overreact to one slate. We’ll be back with another breakdown, but for now, let’s see how today plays out.


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