49ers vs Seahawks Predictions, Picks & Best Bets for the NFC Divisional Round

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The Seattle Seahawks check a lot of the boxes when it comes to their chances of winning the Super Bowl. However, the biggest sticking point in their success is quarterback Sam Darnold.

He regressed down the stretch, and his past playoff performance leaves doubts about his ability to lead the team to a title. The San Francisco 49ers know this and will try to put the ball in Darnold’s hands during Saturday’s Divisional Round matchup.

I forecast plenty of passing from the journeyman QB, which powers my 49ers vs. Seahawks predictions and NFL picks for Saturday, January 19.

49ers vs Seahawks prediction​



49ers vs Seahawks Best bet: Sam Darnold Over 19.5 completions (-102)

Sam Darnold completed 20 of 26 passes in a Week 18 win over the San Francisco 49ers, in which the Seattle Seahawks went run-heavy.

The Niners demonstrated they could stiffen on the ground in the second half of their Wild Card win at Philadelphia, and will sell out to stop Seattle's rushing attack. That leaves Darnold dropping back more.

He’s completed 20+ passes in four of his last five outings and faces a passive 49ers defense that doesn’t bring pressure and allows the fifth-highest completion rate. His projections range from 19.8 to a ceiling of 22 completions in this game.

49ers vs Seahawks same-game parlay​



A rested and ready Seattle team received a huge boost when the schedule forced a banged-up Niners team to travel in a short week for a Saturday showdown.

Darnold will get plenty of dropbacks and a chance to prove his worth against a passive 49ers pass defense. His projections sit as high as 257 passing yards. Jaxon Smith-Njigba is Darnold’s top target and has snatched 7+ catches in 12 of his 17 games this season.

49ers vs Seahawks SGP​

  • Seahawks moneyline
  • Sam Darnold Over 237.5 passing yards
  • Jaxon Smith-Njigba Over 6.5 receptions

Our big-ticket SGP: Best in the Pacific Northwest!​



In a battle between two of the front-runners for Offensive Player of the Year, JSN sees plenty of touches and torches a soft Niners secondary for a touchdown.

With the game script saying San Francisco plays from behind, Christian McCaffrey plays a bigger role as a receiver and keeps the touchdowns coming after striking twice in Philly.

49ers vs Seahawks SGP​

  • Jaxson Smith-Njigba anytime touchdown
  • Jaxson Smith-Njigba Over 6.5 receptions
  • Christian McCaffrey anytime touchdown
  • Christian McCaffrey Over 6.5 receptions

49ers vs Seahawks odds​

  • Spread: 49ers +7.5 (-110) | Seahawks -7.5 (-110)
  • Moneyline: 49ers +280 | Seahawks -360
  • Over/Under: Over 45 (-110) | Under 45 (-110)

More NFL picks and odds from Covers​


49ers vs Seahawks trend to know​


Since becoming Seattle's head coach, Mike Macdonald is 8-4 SU, 7-5 ATS, and owns a 5-7 O/U record against NFC West rivals. Find more NFL betting trends for 49ers vs. Seahawks.

How to watch 49ers vs Seahawks​

LocationLumen Field, Seattle, WA
DateSaturday, January 17, 2026
Kickoff8:00 p.m. ET
TVFOX

49ers vs Seahawks latest injuries​



49ers vs Seahawks weather​


Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.


Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.



This article originally appeared on Covers.com, read the full article here

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