Opening NFL Week 12 Odds and Betting Lines: Colts +3.5 at Chiefs

ASFN Admin · Nov 16, 2025

NFL Week 12 is a little short on marquee matchups, but there is still plenty of betting intrigue.

Of all the games on the slate, the Indianapolis Colts vs. Kansas City Chiefs clash is the most interesting. KC was -4.5 on the look-ahead line, but reopened at -3.5 after losing in Denver on Sunday.

The Los Angeles Rams host the Tampa Bay Buccaneers as 6.5-point favorites. Both teams are coming off tough games, with the Rams narrowly beating the Seahawks (despite Sam Darnold's four interceptions) and the Bucs just couldn't overcome the Buffalo Bills. This is still a bout between contenders worth keeping an eye on.

Here's a full look at the NFL Week 12 slate and all the early odds, starting with Buffalo vs. Houston on Thursday Night Football.

NFL odds Week 12

Matchup	Spread	Moneyline	Over/Under
You must be registered for see images Bills vs You must be registered for see images Texans	Texans +4.5	Bills -200 Texans +168	43.5
You must be registered for see images Vikings vs You must be registered for see images Packers	Packers -6.5	Vikings +235 Packers -290	42.5
You must be registered for see images Colts vs You must be registered for see images Chiefs	Chiefs -3.5	Colts +172 Chiefs -205	49.5
You must be registered for see images Patriots vs You must be registered for see images Bengals	Bengals +7	Patriots -355 Bengals +285	50.5
You must be registered for see images Steelers vs You must be registered for see images Bears	Bears -3	Steelers +136 Bears -162	44.5
You must be registered for see images Jets vs You must be registered for see images Ravens	Ravens -14.5	Jets +750 Ravens -1200	44.5
You must be registered for see images Giants vs You must be registered for see images Lions	Lions -11.5	Giants +540 Lions -770	48.5
You must be registered for see images Seahawks vs You must be registered for see images Titans	Titans +12.5	Seahawks -820 Titans +570	42.5
You must be registered for see images Jaguars vs You must be registered for see images Cardinals	Cardinals +2.5	Jaguars -138 Cardinals +118	46.5
You must be registered for see images Browns vs You must be registered for see images Raiders	Raiders -3	Browns +132 Raiders -156	37.5
You must be registered for see images Eagles vs You must be registered for see images Cowboys	Cowboys +3.5	Eagles -205 Cowboys +172	51.5
You must be registered for see images Falcons vs You must be registered for see images Saints	Saints +2.5	Falcons -132 Saints +112	40.5
You must be registered for see images Buccaneers vs You must be registered for see images Rams	Rams -6.5	Buccaneers +260 Rams -320	49.5
You must be registered for see images Panthers vs You must be registered for see images 49ers	49ers -7	Panthers +270 49ers -335	47.5

Lines as of 11-16

Bills vs Texans odds (Thursday, 8:15 p.m. ET, Prime Video)

Opening line

Texans +2.5
Over/Under 45.5
View full Bills vs. Texans odds and matchup
Read our Bills vs. Texans picks and predictions (coming soon)

Opening line analysis coming soon!

Also see: full Thursday Night Football odds

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