NFL schedule release: Lions to meet Bills in Week 2 stadium debut

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The Detroit Lions are set to meet the Buffalo Bills in a historic Week 2 primetime matchup on Amazon Prime Video. The two teams revealed their Week 2 date will be played on Thursday, Sept. 17 at 8:15 p.m. ET.

It will be the first game ever played at the Bills' brand new Highmark Stadium. The last time these two teams met was in a 48-42 thriller that the Bills won at Ford Field on Dec. 15, 2024. It was one of just two regular-season losses for the Lions in 2024 en route to the NFC's No. 1 seed.

Lions quarterback Jared Goff passed for 494 yards and five touchdowns. Bills quarterback Josh Allen countered with 362 passing yards and four total touchdowns.

Buffalo enters 2026 after a 12-5 season that ended in the AFC divisional round at Denver. The Lions were 9-8 in 2025, missing the playoffs for the first time since 2022.

For more Lions coverage, follow us on X, @TheLionsWire, and give our Facebook page a like. Follow Josh on X, @JoshOnLions

This article originally appeared on Lions Wire: NFL schedule release: Lions to meet Bills in Week 2 stadium debut


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