Cowboys injuries: Tyler Guyton (ankle) not expected to play this week

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What an epic finish in another chapter of a historic rivalry. The Dallas Cowboys overcame a 21-0 deficit at home over the Philadelphia Eagles. With the win, Dallas may have saved their season. Yet, there’s no time to savor the sweet taste of victory over the Eagles as the Cowboys face the AFC champion Kansas City Chiefs on Thursday. After today’s walk-through, here’s where the Cowboys are regarding injuries.

Quinnen Williams not on the Cowboys injury report pic.twitter.com/41hzOmcbOM

— Jon Machota (@jonmachota) November 24, 2025

Bad news coming out of the win. Tyler Guyton suffered a high-ankle sprain against the Eagles that will keep him out for some time. He didn’t participate in practice today and is likely to miss the game against the Chiefs.

Left tackle Tyler Guyton is dealing with a high ankle sprain and is unlikely to be available Thursday vs. the Chiefs, per multiple sources. Nate Thomas would start.

— Todd Archer (@toddarcher) November 24, 2025

Also, listed as DNPs today were Osa Odighizuwa (elbow), George Pickens (knee/calf), and KaVontae Turpin (shoulder/illness). Among those limited today were Jadeveon Clowney (neck), Dante Fowler (shoulder), Malik Hooker (toe/thigh), and Donovan Wilson (neck). However, Tyler Smith (knee) and Solomon Thomas (calf) were full participants today.

For the Chiefs, guard Trey Smith (ankle) did not practice today, nursing an ankle injury of his own that is expected to keep him out for Thursday’s game as well. Smith was elected to the Pro Bowl last season; therefore, his absence would be a big blow to Kansas City. Also, running back Isaiah Pacheco (knee) and Patrick Mahomes (groin) were full participants today. Receivers Rashee Rice (hamstring) and Xavier Worthy (ankle) were limited on Monday. Lastly, tight end Noah Gray (concussion) did not practice after sustaining an injury on Sunday against the Indianapolis Colts.

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