Marvin Harrison Jr. injury update for Cardinals vs. 49ers in Week 11

[ASFN Admin]

At 3-6, the Arizona Cardinals' season isn't technically over, but it sure feels like it. Barring a miraculous late-season run, Jonathan Gannon's Cardinals are seemingly already playing out the string, and in mid-November, no less.

Being without their best offensive weapon against the rival San Francisco 49ers won't help matters.

Second-year receiver Marvin Harrison Jr. will sit out Sunday's game as he recovers from surgery for appendicitis. Harrison will miss at least Sunday's matchup as the Cardinals closely monitor the progress of his recovery next week. Harrison's absence will understandably be a big deal to an Arizona team already thin on true, difference-making receivers and playmakers:

#AZCardinals WR Marvin Harrison Jr. recently underwent surgery for appendicitis and is out this week with the potential for additional weeks. pic.twitter.com/yzKUvmTZI2

— Ian Rapoport (@RapSheet) November 12, 2025

Veteran quarterback Jacoby Brissett will now try to execute a coherent game plan without Harrison, which is obviously easier said than done.

Who is Marvin Harrison Jr.'s backup on the Cardinals?​

Xavier Weaver is officially listed as Harrison's backup on Arizona's depth chart. Weaver is a former undrafted free agent in his second NFL season.

This article originally appeared on For The Win: Marvin Harrison Jr. injury update: Is Cardinals WR playing against 49ers on Sunday?

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