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Happy gameday one and all.
The Arizona Cardinals are taking on their division rival San Francisco 49ers this afternoon and it is going to be a big one.
The Niners are hurting, the Cardinals are hurting and it is only week three, so getting these wins early could prove important later in the season.
Here is everything you need to know about this afternoons game.
Week 3: Arizona Cardinals vs San Francisco 49ers
Date: Sunday, September 21, 2025
Time: 1:25 p.m. AT
Location: Levi’s Stadium — Santa Clara, CA
National TV: Fox (Channel 10 locally)
National online streaming: NFL+, Fox Streaming
TV announcers: Adam Amin (play-by-play) Mark Sanchez (analyst) Kristina Pink (sideline)
Radio: Arizona Sports 98.7 FM
Radio announcers: Dave Pasch (play-by-play), A.Q. Shipley (analyst) and Paul Calvisi (sideline)
NationalRadio: ESPN Radio – Chris Carlin (play-by-play), Kelly Stouffer (analyst)
Spanish Radio: Fuego Radio 106.7 FM
Spanish Radio announcers: Luis Hernandez (play-by-play) and Irving Villanueva (analyst)
Betting line: Cardinals +2.5 per FanDuel Sportsbook
Let’s go Cardinals!
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